Chimica Organica 1
Scienza dei materiali - anno accademico 2025-2026
Primo semestre
Informazioni sul corso e materiale didattico
Chimica Organica 2
Chimica Organica 2
Chimica Industriale - anno accademico 2025-2026
Primo semestre
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Progetti di Tesi Magistrale disponibili per studentesse e studenti della Laurea Magistrale in Chimica, Chimica Industriale e Scienza dei Materiali.
Per ulteriori informazioni contattare Michele Maggini (michele.maggini@unipd.it) o Luka Ðorđević (luka.dordevic@unipd.it) - Edificio 170 (Organica Nuova), 2° piano, stanza 7 - Organic synthesis and materials group
Project 1a. This Thesis project aims to fighting cancer by discovering antitumoral drugs that inhibits the protein kinase NEK6. We target NEK6 because it is overexpressed in several solid human cancers, and because none of the natural and synthetic NEK6 inhibitors, reported to date, has entered clinical trials for cancer treatment yet.
Project 1b. Cellular senescence contributes to age-related diseases, making senolytic therapies a priority. Heat Shock Protein 90 (HSP90) inhibitors show potential but face limitations in toxicity, formulation, and cost. To address these challenges, a virtual screening identified a potent xanthine-derived scaffold (nM IC50), which this project seeks to advance through an efficient, scalable synthesis and a computationally guided library of derivatives to deliver optimized HSP90 inhibitors with improved senolytic activity.
Skills acquisition
Organic synthesis of heterocyclic molecular structures, and their characterization (NMR, IR, mass spectrometry, HPLC)
Collaborations
CNR-SCITEC Roma (molecular modeling, virtual screening)
Università Cattolica del S.C. - IRCSS Pol. Gemelli Roma (biological tests)
Politecnico di Milano, Dipartimento di Chimica, Materiali e Ingegneria Chimica (optical spectroscopies characterization)
K. Hu et al. J. Phys. Chem. B 129, 9097 (2025)
P. Zardi et al. Archives Biochem. Biophys. 768, 110391 (2025)
DOI: 10.1016/j.abb.2025.110391
Project 2. This Thesis project deals with the functionalization of the hydrocarbon cubane for the preparation of hydrogen-bonded organic frameworks (HOFs). The strategic functionalization of cubane with symmetrically arranged carboxylic, amine, or sulfonic groups allows the construction of extended supramolecular architectures with potential high structural and dynamic performance. Additionally, cubane’s intrinsic strain energy, when embedded within a crystalline matrix, can be evenly distributed and potentially released in a controlled manner, providing a unique energetic dimension - HOF-cube
Skills acquisition
Organic synthesis of new cubane derivatives and their characterization (NMR, IR, mass spectrometry, HPLC); specific skills on small-scale synthesis of reactive products and intermediates.
The pyramidalized olefin cubene
Project 3. This Thesis project deals with the synthesis of polycyclic heteroaromatic compounds (PAHs) as functional chromophores and organic semiconductors. Replacing carbon atoms in the PAHs structure with other isolobal atoms, or heteroatom doping, is emerging as a powerful approach to control the chemical, supramolecular, and optoelectronic properties of PAHs for their use, for example, as organic semiconductors in solar cells or chromophores in photocatalysis.
Skills acquisition
Organic synthesis (including the use of air-free techniques), characterization (NMR, IR, mass and HPLC), optoelectronic characterization (UV-Vis, fluorescence, electrochemistry), test applications of the newly synthesized chromophores (optional).
Ðorđević et al. Angew. Chem. Int. Ed. 62, e202214997 (2023)
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