Master Thesis projects

Inhibition of protein kinase NEK6

This Thesis project aims to fighting cancer and CNS pathologies (ALS/FTD) by discovering active molecules that inhibits the protein kinase NEK6.

Skills acquisition

Organic synthesis of heterocyclic molecular structures, and their characterization (NMR, IR, mass spectrometry, HPLC). The activity is supported by an interdisciplinary network of collaborators, combining complementary expertise in computational chemistry, biological evaluation, and advanced physico-chemical characterization. 

HOF-cube

This Thesis project focuses on the systematic functionalization of cubane to build hydrogen-bonded organic frameworks (HOF). Symmetric introduction of carboxylic, amine, or sulfonic groups enables the formation of extended supramolecular architectures with promising structural and dynamic properties. The intrinsic strain energy of cubane, embedded in a crystalline matrix, may also be harnessed and released in a controlled manner, adding a unique energetic feature.

Skills acquisition

Organic synthesis of new cubane derivatives and their characterization (NMR, IR, mass spectrometry, HPLC); specific skills on small-scale synthesis of reactive products and intermediates. 

Smart materials for precision soil management

This thesis project focuses on multifunctional biodegradable materials for soil amendment, aimed at reducing water use and the environmental impact of fertilizers and pesticides while improving plant growth, nutrient uptake, and stress tolerance. The integration of MXenes - conductive, water-dispersible 2D materials - may further enhance mechanical properties and enable responsive systems for real-time sensing of soil conditions.

Skills acquisition

Synthesis and functionalization of biodegradable materials and their characterization; skills in incorporating nanostructured additives, designing controlled-release systems, and developing responsive materials.