Master Thesis projects

Inhibition of protein kinase NEK6

This Thesis project aims to fighting cancer and CNS pathologies (ALS/FTD) by discovering active molecules that inhibits the protein kinase NEK6.

Skills acquisition

Organic synthesis of heterocyclic molecular structures, and their characterization (NMR, mass spectrometry, optical spectroscopies, HPLC). The activity is supported by an interdisciplinary network of collaborators, combining complementary expertise in computational chemistry, biological evaluation, and advanced physico-chemical characterization. 

HOF-cube

This Thesis project focuses on the systematic functionalization of cubane to make hydrogen-bonded organic frameworks (HOFs). Symmetric introduction of carboxylic, amine, or sulfonic groups enables extended supramolecular architectures. The intrinsic strain energy of cubane, embedded in a crystalline matrix, may be harnessed and released in a controlled manner, offering a unique energetic feature.

Skills acquisition

Small-scale synthesis of reactive cubane-based products and intermediates and their characterization (NMR, mass spectrometry). Methods for the preparation of HOFs.

[60]fullerene in NMR hyperpolarization

This project focuses on the synthesis of fullerene nitroxides as molecular probes to investigate light-driven NMR hyperpolarization mechanisms, aiming to enhance signal sensitivity beyond thermal equilibrium limits, in collaboration with the hyperpolarized NMR lab at DiSC.

Skills acquisition

Synthesis, purification and characterization of functionalized [60]fullerenes.

Smart materials for precision soil management

This Thesis project focuses on functional biodegradable materials for soil amendment, aimed at reducing water use and the environmental impact of fertilizers and pesticides while improving plant growth, nutrient uptake, and stress tolerance. The integration of MXenes - conductive, water-dispersible 2D materials, may further enhance mechanical properties and enable responsive systems for real-time sensing of soil conditions.

Skills acquisition

Synthesis and formulation of biodegradable materials and their characterization; skills in incorporating nanostructured additives, designing controlled-release systems, and developing responsive materials.